Publications

Sona Pekova, MD graduated from Charles University in Hradec Kralove, Czech Republic. She continued her PhD. studies at the Academy of Sciences of the Czech Republic in Prague and the 1’t Medical Faculty, Charles University in Prague, Czech Republic. Her PhD. is in molecular biology, virology and immunology. Sona Pekova also has extensive expertise in molecular hematology, molecular hematooncology, molecular microbiology and human genetics, with many peer reviewed scientific papers documenting her medical and scientific history (see the list of publications below).

Antifungal effects of the biological agent Pythium oligandrum observed in vitro.
Naderadskd M, Fridrichov6 M, Kellnerov6 D, Pekovf S, L6ny P. J Feline Med Surg, 20L61uL14.
pii: 10986 1 2X1665869 0.

Mantle cell lymphoma-variant Richter syndrome: Detailed molecular-cytogenetic and backtracking analysis reveals slow evolution of a pre-MCL clone in parallel with CLL over several years.
Naderadskd M, Fridrichov6 M, Kellnerov6 D, Pekovf S, L6ny P. J Feline Med Surg, 20L61uL14.
pii: 10986 1 2X1665869 0.

Multilocus Sequence Analysis of Clinical “Candidatus Neoehrlichia mikurensis” Strains from Europe.
Grankvist A, Moore ER, Svensson Stadler L, Pekova S, Bogdan C, Geif3dorfer W, Grip-Lind6n
J, Brandstrom K, Marsal J, Andr6asson K Lewerin C, Welinder-Olsson C, WennerAs C. I Clin
Microbiol.2015 Oct;53[L0):3126-32. doi: L0.II2B/|CM.00BB0-15. Epub 2015Jul B.

Comprehensive Analyses of White-Handed Gibbon Chromosomes Enables Access to 92 Evolutionary Conserved Breakpoints Compared to the Human Genome.
Weise A, Kosyakova N, Voigt M, Aust N, Mrasek K, Lohmer S, Rubtsov N, Karamysheva TV
Trifonov VA, Hardekopf D, Jandu5kov6 T, Pekova S, Wilhelm K, Liehr T, Fan X, Cytogenet
Genome Res.2015;145(1):42-9. doi: 10.1159 /000381764. Epub 2015 Apr24.

Long term follow-up in a patient with a de novo microdeletion of 14q11.2 involving CHD8.
Drabova f, Seemanova E, Hancarova M, Pourova R” Horacek M, fancuskova T, Pekova S,
Novotna D, Sedlacek Z. Am I Med Genet A. 2075 Apr;1.67A(4):837-47. doi:
L0.7002/ajmg.a.36957. Epub 2015 Mar 3.

Molecular characterization of the rare translocation t(3;10)(q26;q21) in an acute myeloid leukemia patient.
fancuskova T, Plachy R, Zemankova L, Hardekopf DW, Stika J, Zejskova L, Praulich I, Kreuzer
KA, Rothe A, Othman MA, Kosyakova N, Pekova S. Mol Cytogenet.20L4JultS;7:47. doi:
10.LIB6 / 17 55 -8L66-7 -47. eCollection 20L4.

Infections with the tick-borne bacterium “Candidatus Neoehrlichia mikurensis” mimic noninfectious conditions in patients with B cell malignancies or autoimmune diseases.
Grankvist A, Andersson PO, Mattsson M, Sender M, Vaht K, Hoper L, Sakiniene E, Trysberg E,
Stenson M, Fehr f, Pekova S, Bogdan C, Bloemberg G, Wenneris C. Clin Infect Dls. 201,4
Jun;58[12):7716-22. doi: 10,1093 /cid/ciu199. Epub 2014 Mar 18,

A method to identify new molecular markers for assessing minimal residual disease in acute leukemia patients.
fancuskova T, Plachy R” Stika J, Zemankova L, Hardekopf DW, Liehr T, Kosyakova N, Cmejla R”
Zejskova L, Kozak T,ZakP, Zavrelova A, Havlikova P, Karas M, Junge A, Ramel C, Pekova S.
Leuk Res. 20L3 Oct;37 [10):1,363-73. doi: L0.70L6/j.1eukres,2013,06.009. Epub 2013 ld 77.

Pathogenetic role of ETV6 fusion gene in leukemic transformation of myelodysplastic syndrome refractory anemia with excess blasts-1 with a new, rare translocation t(11;19)(q24.3;q13.12) and insertion ins(6;12)(p22.3p13).
faro5ov6 M, Rohofi P,ZivnA f, Pekovd S, Nedomovd R, Holzerov6 M, Midkovd P, Reptov6 S, Papajik T, Indr6k K,
Leuk Lymphoma.2014 Apr;55[4):950-3. doi: 10.31.09/L0428794.20L3.81.4L27. Epub 2013
lul29. No abstract available.

Infective endocarditis due to Bartonella quintana: a severe disease and underdiagnosed etiology.
DZupov6 O, Pekovd S, Sojkov6 N, Feuereisl R, Bene5 f .
Folia Microbiol [Praha). 20t3 Nov;58[6):491-4. doi: 10.1007/s12223-013-0235-9. Epub
2013 Mar 2. No abstract available.

DNA released by leukemic cells contributes to the disruption of the bone marrow microenvironment.
Dvoi6kovd M, Karafi6t V, Pajer P, Kluz6kov6 E, Jarkovskd K, Pekovii S, Krutilkov|L, Dvoi6k
M. Oncogene.20L3 Oct31.;32(44):5207-9. doi: 10.1038 /onc.2072.553. Epub 2072Dec \0.

[Patient with B-CLL with a history of unrelated hematopoietic cells donation–retrospective analysis of CLL development and implication for the recipient].
Jindra P, Žejšková L, Peková S, Navrátilová J, Schutzová M, Vokurka S, Koza V.
Klin Onkol. 2012;25(3):212-5. Czech.
PMID: 22724571

Severe intellectual disability, omphalocele, hypospadia and high blood pressure associated to a deletion at 2q22.1q22.3: case report.
Mulatinho MV, de Carvalho Serao CL, Scalco F, Hardekopf D, Pekova S, Mraqek K, Liehr T,
Weise A, Rao N, Llerena JC Jr. Mol Cytogenet, 20L2lun 11;5(1):30. doi: 10.1186/1755-8166-
5-30,

How to narrow down chromosomal breakpoints in small and large derivative chromosomes–a new probe set.
Hamid AB, Kreskowski K, Weise A, Kosayakova N, Mrasek K, Voigt M, Guilherme RS, Wagner
R, Hardekopf D, Pekova S, Karamysheva T, Liehr T, Klein E.
I Appl Genet. 2012 Aug;53(3):259-69, doi: L0,1007/s13353-072-0098-9.Epub 20LZ Apr 29.

Microdeletion and microduplication syndromes.
Weise A, Mrasek K, Klein E, Mulatinho M, Llerena lC lr, Hardekopf D, Pekova S, Bhatt S,
Kosyakova N, Liehr T. I Histochem Cytochem. 2072 May;60(5):346-58. doi:
70.7369/00221.55472440001. Epub 2012 Mar 6. Review.

The effects of siRNA-mediated RGS4 gene silencing on the whole genome transcription profile: implications for schizophrenia.
Vrajovd M, Pekovd S, HordcekJ, Hoschl C, Neuro Endocrinol Lett.20II;32(3):246-52.

Candidatus Neoehrlichia mikurensis infection identified in 2 hematooncologic patients: benefit of molecular techniques for rare pathogen detection.
Pekova S, Vydra f, Kabickova H, Frankova S, Haugvicova R, Mazal O, Cmejla R, Hardekopf DW,
Jancuskova T, Kozak T. Diagn Microbiol Infect Dis. 201’L Mar;69(3):266-70. doi:
1,0.1,0 16 / j.diagmicrobio.2 0 1 0. 1 0.0 04.

A comprehensive study of TP53 mutations in chronic lymphocytic leukemia: Analysis of 1287 diagnostic and 1148 follow-up CLL samples.
Pekova S, Mazal O, Cmejla R, Hardekopf DW, Plachy R, Zejskova L, Haugvicova R, Jancuskova T, Karas M, Koza V, Smolej L, Bezdickova L, Kozak T.
Leuk Res. 2011 Jul;35(7):889-98. doi: 10.1016/j.leukres.2010.12.016. Epub 2011 Jan 13.

Angiopoietin-2 mRNA expression is increased in chronic lymphocytic leukemia patients with poor prognostic features.
Vrbacky F, Smolej L, Vroblova V, Pekova S, Hrudkova M, Cervinka M, Pecka M, Krejsek J, Maly J.
Hematology. 2010 Aug;15(4):210-4. doi: 10.1179/102453309X12583347113898.

Expression of the hippocampal NMDA receptor GluN1 subunit and its splicing isoforms in schizophrenia: postmortem study.
Vrajová M, Stastný F, Horácek J, Lochman J, Serý O, Peková S, Klaschka J, Höschl C.
Neurochem Res. 2010 Jul;35(7):994-1002. doi: 10.1007/s11064-010-0145-z. Epub 2010 Mar 5.

Molecular variability of FLT3/ITD mutants and their impact on the differentiation program of 32D cells: implications for the biological properties of AML blasts.
Pekova S, Ivanek R, Dvorak M, Rueggeberg S, Leicht S, Li X, Franz T, Kozak T, Vrba J, Koza V, Karas M, Schwarz J, Cetkovsky P, Prucha M.
Leuk Res. 2009 Oct;33(10):1409-16. doi: 10.1016/j.leukres.2009.01.004. Epub 2009 Jan 31.

Genomic polymorphism and sepsis–is there a reason for optimism?
Průcha M, Zazula R, Peková S.
Prague Med Rep. 2008;109(2-3):113-26. Review.

Quantitation of minimal residual disease in patients with chronic lymphocytic leukemia using locked nucleic acid-modified, fluorescently labeled hybridization probes and real-time PCR technology.
Peková S, Bezdícková L, Smolej L, Kozák T, Hochová I, Zák P, Tomsíková L, Průcha M.
Mol Diagn Ther. 2007;11(5):325-35.

Identification of somatic hypermutations in the TP53 gene in B-cell chronic lymphocytic leukemia.
Malcikova J, Smardova J, Pekova S, Cejkova S, Kotaskova J, Tichy B, Francova H, Doubek M, Brychtova Y, Janek D, Pospisilova S, Mayer J, Dvorakova D, Trbusek M.
Mol Immunol. 2008 Mar;45(5):1525-9. Epub 2007 Oct 24.

Most pediatric patients with essential thrombocythemia show hypersensitivity to erythropoietin in vitro, with rare JAK2 V617F-positive erythroid colonies.
Veselovska J, Pospisilova D, Pekova S, Horvathova M, Solna R, Cmejlova J, Cmejla R, Belickova M, Mihal V, Stary J, Divoky V.
Leuk Res. 2008 Mar;32(3):369-77. Epub 2007 Aug 23.

Identification of a novel, transactivation-defective splicing variant of p53 gene in patients with chronic lymphocytic leukemia.
Pekova S, Cmejla R, Smolej L, Kozak T, Spacek M, Prucha M.
Leuk Res. 2008 Mar;32(3):395-400. Epub 2007 Aug 3.

Plasma levels of basic fibroblast growth factor and vascular endothelial growth factor and their association with IgVH mutation status in patients with B-cell chronic lymphocytic leukemia.
Smolej L, Andrys C, Peková S, Schwarz J, Belada D, Zák P.
Haematologica. 2006 Oct;91(10):1432-3.

Mutated or non-mutated? Which database to choose when determining the IgVH hypermutation status in chronic lymphocytic leukemia?
Peková S, Baran-Marszak F, Schwarz J, Matoska V.
Haematologica. 2006 Mar;91(3):ELT01.

[Isolated lymphadenopathy as the first presentation of systemic mastocytosis–description of two cases].
Kinkor Z, Síma R, Skálová A, Boudová L, Peková S, Dvoráková D, Dĕdic K, Kracík M, Janousek M, Michal M.
Cesk Patol. 2006 Jan;42(1):34-8. Czech.

Touch-down reverse transcriptase-PCR detection of IgV(H) rearrangement and Sybr-Green-based real-time RT-PCR quantitation of minimal residual disease in patients with chronic lymphocytic leukemia.
Peková S, Marková J, Pajer P, Dvorák M, Cetkovský P, Schwarz J.
Mol Diagn. 2005;9(1):23-34.

Incidence of chromosomal anomalies detected with FISH and their clinical correlations in B-chronic lymphocytic leukemia.
Sindelárová L, Michalová K, Zemanová Z, Ransdorfová S, Brezinová J, Peková S, Schwarz J, Karban J, Cmunt E.
Cancer Genet Cytogenet. 2005 Jul 1;160(1):27-34.

A single administration of gemtuzumab ozogamicin for molecular relapse of acute promyelocytic leukemia.
Schwarz J, Marková J, Peková S, Trnková Z, Sponerová D, Cetkovský P.
Hematol J. 2004;5(3):279-80. No abstract available.

Type J CBFbeta/MYH11 transcript in the M4Eo subtype of acute myeloid leukemia.
Trnková Z, Peková S, Bedrlíková R, Záková D, Zemanová Z, Polák J, Michalová K, Cermák J, Schwarz J.
Hematology. 2003 Apr;8(2):115-7.

[Expression of cyclin-dependent kinase inhibitors in leukemia].
Polák J, Peková S, Schwarz J, Kozák T, Haskovec C.
Cas Lek Cesk. 2003 Jan 20;142(1):25-8. Czech.